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Major Presentations and Research Articles

 
 
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Comparison of immunogenicity between candidate influenza A(H3N2)virus vaccine strains in Japan: A randomized controlled trial using amonovalent  vaccine of A/Saitama/103/2014 (CEXP-002) and A/HongKong/4801/2014 (X-263)
Tetsuo Kase, Megumi Inoue, Saeko Morikawa, Hiroko Kumashiro, Satoshi Hiroi, Keiko Nakata, Kazuya Ito,
Motoki Ishibashi, Tomomi Tsuru, Shin Irie, Akiko Maeda, Satoko Ohfuji, Wakaba Fukushima, Yoshio Hirota

Evaluation of Assay Sensitivity and the Concentration-Effect Relationship of Moxifloxacin in a QT/QTc Study in Japan.
Shiramoto M, Uchimaru H, Kaji Y, Matsuguma K, Matsuki S, Ikushima I, Yonou M, Irie S.Ther Innov Regul Sci. 2014 Mar;48(2):181-189.

Pharmacokinetic and pharmacogenomic profiles of telmisartan after the oral microdose and therapeutic dose.
Ieiri I, Nishimura C, Maeda K, Sasaki T, Kimura M, Chiyoda T, Hirota T, Irie S, Shimizu H, Noguchi T, Yoshida K, Sugiyama Y.Pharmacogenet Genomics 21(8): 495-505 (2011)

Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose.
Ieiri I, Doi Y, Maeda K, Sasaki T, Kimura M, Hirota T, Chiyoda T, Miyagawa M, Irie S, Iwasaki K, Sugiyama Y.J Clin Pharmacol 52(7): 1078-89 (2012)

Microdose Study of 14C-Acetaminophen with accelerator mass spectrometry to examine pharmacokinetics of parent drug metabolites in healthy subjects.
Tozuka Z, Kusuhara H, Nozawa K, Hamabe Y, Ikushima I, Ikeda T and Sugiyama Y.Clin Pharmacol Ther 88: 824-830 (2010).

Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.
Ieiri I, Fukae M, Maeda K, Ando Y, Kimura M, Hirota T, Nakamura T, Iwasaki K, Matsuki S, Matsuguma K, Kanda E, Deguchi M, Irie S, Sugiyama Y.Int. J Clin Pharmacol Ther 50: 689-700 (2012)

Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam(CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.
Ieiri I, Tsunemitsu S, Maeda K, Ando Y, Izumi N, Kimura M, Yamane N, Okuzono T, Morishita M, Kotani N, Kanda E, Deguchi M, Matsuguma K, Matsuki S, Hirota T, Irie S, Kusuhara H, Sugiyama Y. J Clin Pharmacol 53(6): 654-6 (2013)

Stereoselective 4′-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.
Ieiri I, Mamiya K, Urae A, Wada Y, Kimura M, Irie S, Amamoto T, Kubota T, Yoshioka S, Nakamura K, Nakano S, Tashiro N, Higuchi S.Br J Clin Pharmacol. 1997 Apr;43(4):441-5.

Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism.
Suwannakul S, Ieiri I, Kimura M, Kawabata K, Kusuhara H, Hirota T, Irie S, Sugiyama Y, Higuchi S.J Hum Genet (2008) 53: 899-904.

Effect of Duloxetine on Urethral Resting Pressure and on Sphincter Contractility in Response to Coughing and Magnetic Stimulation in Healthy Women.
Yono M, Otani M, Ito K, Inoue Y, Furukawa K, Hori M, Tsuji S, Tanaka T, Sakata Y, Irie S.LUTS:Low Urin Tract Symptoms. 2015 May;7(2):93-8.