Oligonucleotide Therapeutics
Oligonucleotide Therapeutics (ONTs) have been the center of attention in recent years as one of the promising therapeutic options that could meet the unmet needs of many therapeutic areas.
Since the first ONTs were approved in 2008, R&D has been moving ahead full throttle in Japan with active research and discussion among experts.
With the Japanese PMDA’s efforts supporting this new area, SOUSEIKAI has been proud to be a part of the trend, conducting safe early clinical trials for the last 3 years.
There are several kinds of ONTs, such as Antisense oligonucleotides, small interfering RNAs, microRNAs, Aptamers, Decoys, and CpG oligodeoxynucleotides. Our experience includes Antisense ONTs and Aptamers as of 2020, as well as other ONT study capabilities.
Approved Oligonucleotide Therapeutics in Japan (as of February, 2021)
| Generic name | Trade name | Type | Target | Indication | Year approved |
|---|---|---|---|---|---|
| Pegaptanib | Macugen® | Aptamer | VEGF protein | Neovascular (wet) age-related macular degeneration | 2008 |
| Nusinersen | Spinraza® | Antisense | SMN2 pre m-RNA | Spinal muscular atrophy | 2017 |
| Patisiran | Onpattro® | siRNA | TTR mRNA | Polyneuropathy of hereditary transthyretin-mediated amyloidosis | 2019 |
| Viltolarsen | Viltespo | Antisense | Dystrophin pre-mRNA | Duchenne muscular dystrophy | 2020 |
