souseikai global clinical research center

CNS Studies/CSF Sampling

One of our top 3 therapeutic areas is CNS. We conduct about 60-80 CNS-related studies each year safely with our Neurologic and psychiatric Specialists.

In 2013, we developed the procedures and started to conduct studies involving CSF sampling by a lumbar puncture for clinical trials for the first time in Japan. Currently, CSF samplings in healthy volunteers (young & elderly) are only available at SOUSEIKAI.

To date, we have successfully conducted 15 CSF sampling studies.


  • EEG
  • MRI
  • CSF Sampling
  • CogState
  • Clinical Dementia Rating (CDR)
  • Karolinska Sleepiness Scale (KSS)
  • Digital Symbol Substitution Test (DSST)
  • Columbia Suicide Severity Rating Scale (C-SSRS)
  • Actiwatch
  • Computerized Psychomotor Vigiliance Test(CPVT)
  • DSM-IV
  • Mini-Mental State Examination(MMSE)
  • State-Trait Anxiety Inventory(STAI)
  • Simulator Sickness Questionnaire
  • Driving Simulator
  • Leeds Sleep Evaluation Questionnaire (LSEQ)
  • Wechsler Memory Scale-Revised (WMS-R)
  • Epworth Sleepiness Scale (ESS)
  • Polysomnography Test (PSG)
  • Profile of Mood States (POMS)
  • Krapelin Test
  • Saccadic Eye Movement (SEM) Test
  • Maintenance of Wakefulness Test(MWT)
  • McGill's Pain Questionnaire
  • Cold Pressor Pain Evaluation