souseikai global clinical research center

Achievements - 2017

The list includes Japanese literature.


  • 中村好一、川村孝、福島若葉、「橋本修二:難病の患者数と臨床疫学像把握のための全国疫学調査マニュアル第3版」中村好一、廣田良夫(監).厚生労働科学研究費補助金.難治性疾患等政策研究事業(難治性疾患政策研究事業).難治性疾患の継続的な疫学データの収集・解析に関する研究班(研究代表者 中村好一).2017年1月
  • Kuriyama N, Miyajima M, Nakajima M, Kurosawa M, Fukushima W, Watanabe Y, Ozaki E, Hirota Y, Tamakoshi A, Mori E, Kato T, Tokuda T, Urae A, Arai H. "Nationwide hospital-based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics." Brain Behav 7(3):e00635 (2017). doi: 10.1002/brb3.635. eCollection 2017 Mar.
  • Tanaka K, Miyake Y, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Nakamura Y, Fukuoka Kinki Parkinson’s Disease Study Group. Vitamin D receptor gene polymorphisms, smoking, and risk of sporadic Parkinson’s disease in Japan. Neurosci Lett 643:97-102, 2017.
  • Nakashima K, Aoshima M, Ohfuji S, Suzuki K, Katsurada M, Katsurada N, Misawa M, Otsuka Y, Kondo K, Hirota Y. "Immunogenicity of trivalent influenza vaccine in patients with lung cancer undergoing anticancer chemotherapy." Hum Vacci Immunother 13(3):543-550, 2017.
  • Hirota Y, Ozasa K, Nakano T. "Vaccine epidemiology: Its role in promoting sound immunization programs in Japan." Vaccine 35: 4787–4790, 2017.
  • Hara M, Hirota Y. "Basic principle of population-based cohort study to evaluate influenza vaccine effectiveness among older Japanese." Vaccine 35: 4791–4795, 2017.
  • Fukushima W, Hirota Y. "Basic principles of test-negative design in evaluating influenza vaccine effectiveness." Vaccine 35: 4796-4800, 2017.
  • Ohfuji S, Okada K, Nakano T, Ito H, Hara M, Kuroki H, Hirota Y. "Control selection and confounding factors: a lesson from a Japanese case-control study to examine acellular pertussis vaccine effectiveness." Vaccine 35: 4801-4805, 2017.
  • Kondo K, Suzuki K, Washio M, Ohfuji S, Fukushima W, Maeda A, Hirota Y, and the Study Group for Pneumonia in the Elderly Individuals. "Effectiveness of 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccine for pneumonia among the elderly –selection of controls in a case-control study–." Vaccine 35: 4806-4810, 2017.
  • Ohfuji S, Deguchi M, Tachibana D, Koyama M, Takagi T, Yoshioka T, Urae A, Fukushima W, Hirota Y, for the Osaka Pregnant Women Influenza Study Group. "Estimating influenza disease burden among pregnant women: application of self-control method. Vaccine 35: 4811-4816, 2017.
  • Fukushima W, Ozasa K, Okumura A, Mori M, Hosoya M, Nakano T, Tanabe T, Yamaguchi N, Suzuki H, Mori M, Hatayama H, Ochiai H, Kondo K, Ito K, Ohfuji S, Nakamura Y, Hirota Y. "Oseltamivir use and severe abnormal behavior in Japanese children and adolescents with influenza: Is a self-controlled case series study applicable?" Vaccine 35: 4817-4824, 2017.
  • Ohfuji S, Kobayashi M, Ide Y, Egawa Y, Saito T, Kondo K, Ito K, Kase T, Maeda A, Fukushima W, and Hirota Y. Key points in evaluating immunogenicity of pandemic influenza vaccines: A lesson from immunogenicity studies of influenza A(H1N1)pdm09 vaccine. Vaccine 35(39):5303-5308, 2017.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Hirota Y. "Rate of eating in early life is positively associated with current and later BMI among young Japanese children: the Osaka Maternal and Child Health Study." Nutrition Research 37: 20-28, 2017.
  • Fukushima W, Morikawa S, Fujioka M, Matsushita T, Kubota M, Yagi Y, Takasaki Y, Shindo S, Yamashita Y, Yokoyama T, Kiyomatsu Y, Hiroi S, Nakata K, Ito K, Ohfuji S, Maeda A, Kase T, and Hirota Y, (as Japanese contributors). September 2017 "Interim estimates of influenza vaccine effectiveness for the 2017 southern hemisphere season and final estimates for the 2016/17 northern hemisphere season." WHO Collaborating Centre for Reference and Research on Influenza on behalf of The Global Influenza Vaccine Effectiveness (GIVE) Collaboration. 21st September 2017.
  • Ohfuji S, Ito K, Ishibashi M, Shindo S, Takasaki Y, Yokoyama T, Yokoyama T, Yamashita Y, Shibao K, Nakano T, Tsuru T, Irie S, Hirota Y. "Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: a cohort study in Japan." Medicine (Baltimore) 96 :e7073, 2017.
  • 福島若葉、森川佐依子、藤岡雅司、松下 享、久保田恵巳、武知哲久、高崎好生、進藤静生、山下祐二、横山隆人、清松由美、廣井 聡、中田恵子、前田章子、伊藤一弥、大藤さとこ、加瀬哲男、廣田良夫:「6歳未満児におけるインフルエンザワクチンの有効性:2013/14~2015/16シーズンのまとめ(厚生労働省研究班報告として)」『病原微生物検出情報(IASR)』.38 :223-4, 2017.
  • Washio M, Takahashi H, Kobashi G, Kiyohara C, Tada Y, Asami T, Ide Y, Atsumi T, Horiuchi T, and the Kyushu Sapporo SLE (KYSS) Study Group. "Risk factors for development of systemic lupus erythematosus among Japanese females: medical history and reproductive factors." Int J Rheum Dis. 20(1):76-83, 2017. doi: 10.1111/1756-185X.12600. Epub 2015 Jul 14.
  • Kondo K, Jingushi S, OhfujiS, Sofue M, Itoman M, Matsumoto T, Hamada Y, Shindo H, Takatori Y, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Fujii G, Ohashi H, Fukushima W, Maeda A, Inui M, Takahashi S, Hirota Y. "Factors associated with functional limitation in the daily living activities of Japanese hip osteoarthritis patients." Int J Rheum Dis 20(10):1372-1382, 2017.

Achievements - 2016

The list includes Japanese literature.


  • Washio M, Kondo K, Fujisawa N, Harada E, Tashiro H, Mizokami T, Nogami H, Iwanaga T, Nakanishi Y, Suzuki K, Ohfuji S, Fukushima W, Hirota Y and the Kyushu Task Force for CAP Risk in the Elderly. "Hypoalbuminemia, influenza vaccination and other factors related to the development of pneumonia acquired outside hospitals in southern Japan: A case–control study." Geriatr Gerontol Int t 16(2): 223–229, 2016.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Hirota Y. "Feeding practices in early life and later intake of fruit and vegetables among Japanese toddlers: the Osaka Maternal and Child Health Study." Public Health Nutrition 19(4):650-657, 2016.
  • 廣田良夫:『感染症法、新興再興感染症・輸入感染症、予防接種』岡崎勲、豊嶋英明、小林廉毅(編)、「標準公衆衛生・社会医学 第2版」医学書院、東京、2016.3.15. pp.160-165, 165-183, 189-195.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Hirota Y. "Early sugar-sweetened beverage consumption frequency is associated with poor quality of later food and nutrient intake patterns among Japanese young children: the Osaka Maternal and Child Health Study." Nutrition Research 36:594-6, 2016.
  • Hara M, Hanaoka T, Maeda K, Kase T, Ohfuji S, Fukushima W, Hirota Y. "Immunogenicity and efficacy of A/H1N1pdm vaccine among subjects with severe motor and intellectual disability in the2010/11 influenza season." J Epidemiol 26(6): 300-306, 2016.
  • Washio M, Kondo K, Fukushima W, Ohfuji S, Fujisawa N, Matsumoto T, Tashiro H, Nogami H, Iwanaga T, Nakanishi Y, Kitazono T, Suzuki K, Hirota Y. "Hypoalbuminemia and other factors related to the development of pneumonia acquired outside hospital in the young elderly and the old elderly: the finding from a case-control study in southern Japan." Internal Med J 23(4): 313-315, 2016.
  • Ohfuji S, Jingushi S, Kondo K, Sofue M, Itoman M, Matsumoto T, Hamada Y, Shindo H, Takatori Y, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Fujii G, Ohashi H, Takahashi S, Hirota Y. "Factors associated with diagnostic stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: a cross-sectional study." BMC Musculoskelet Disor 17:320 (2016), DOI 10.1186/s12891-016-1179-4
  • Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Nakamura Y, and Fukuoka Kinki Parkinson’s Disease Study Group. "PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson’s disease in Japan." Journal of the Neurological Sciences. 362: 47–52, 2016.
  • Yagi M, Palacpac N, Ito K, Oishi Y, Itagaki S, Balikagala B, Ntege E, Yeka A, Kanoi B, Katuro O, Shirai H, Fukushima W, Hirota Y, Egwang T. "Antibody titres and boosting after natural malaria infection in BK-SE36 vaccine responders during a follow-up study in Uganda." Sci Rep 6:34363 (2016). doi: 10.1038/srep34363.

Achievements - 2015

The list includes Japanese literature.


  • Ohfuji S, Okada K, Nakano T, Ito H, Hara M, Kuroki H, Hirota Y. "Effectiveness of acellular pertussis vaccine in a routine immunization program: A multicenter, case-control study in Japan." Vaccine 33: 1027-1032, 2015.
  • Hara M, Fukuoka M, Tashiro K, Ozaki I, Ohfuji S, Okada K, Nakano T, Fukushima W, Hirota Y. "Pertussis outbreak in university students and evaluation of acellular pertussis vaccine effectiveness in Japan." BMC Infectious Diseases 15(1):45, 2015. doi:10.1186/s12879-015-0777-3
  • Matsumoto H, Ohfuji S, Watanabe K, Yamagami H, Fukushima W, Maeda K, Kamata N, Sogawa M, Shiba M, Tanigawa T, Tominaga K, Watanabe T, Fujiwara Y, Hirota Y, Arakawa T. "Booster influenza vaccination does not improve immune response in adult inflammatory bowel disease patients treated with immunosuppressives: a randomized controlled trial." J Gastroenterl 50(8):876-886, 2015.
  • Hiroi S, Morikawa S, Nakata K, Maeda A, Kanno T, Irie S, Ohfuji S, Hirota Y, Kase T. "Trivalent influenza vaccine-induced antibody response to circulating influenza a(H3N2) viruses in 2010/11 and 2011/12 seasons." J Hum Vaccin Immunother. 11(2): 386-390, 2015.
  • Okubo H, Miyake Y, Tanaka K, Sasaki S, Hirota Y. "Maternal total caffeine intake, mainly from Japanese and Chinese tea, during pregnancy was associated with risk of preterm birth." Nutrition Research 35: 309-316, 2015.
  • Nakata K, Fujieda M, Miki H, Fukushima W, Ohfuji S, Maeda A, Kase T, Hirota Y. "Detection of influenza vaccine effectiveness among nursery school children: Lesson from a season with cocirculating respiratory syncytial virus." J Hum Vaccin Immunother 11(3): 545-552, 2015.
  • Kondo K, Suzuki K, Washio M, Ohfuji S, Fukushima W, Maeda A, Hirota Y, and the Pneumonia in Elderly People Study Group. "Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study." J Hum Vaccin Immunother 11(5):1088-1093, 2015.
  • Saito T, Ohfuji S, Matsumura T, Saito T, Maeda K, Maeda A, Fukushima W, Fujimura H, Sakoda S, Hirota Y. "Safety of a pandemic influenza vaccine and immune response in patients with Duchenne muscular dystrophy." Intern Med. 54(10): 1199-1205, 2015.
  • Okada C, Fujieda M, Fukushima W, Ohfuji S, Kondo K, Maeda A, Nakano T, Kaji M, Hirota Y. "Reactogenicity of trivalent inactivated influenza vaccine in young children: Pronounced reactions by previous successive vaccinations." Vaccine 33(30):3586-3591, 2015.
  • Takahashi S, Fukushima W, Yamamoto T, Iwamoto Y, Kubo T, Sugano N, Hirota Y. "Temporal trends in characteristics of newly diagnosed nontraumatic osteonecrosis of the femoral head from 1997 to 2011: A hospital-based sentinel monitoring system in Japan." J Epidemiol 25(6): 437-444, 2015.
  • Nakashima K, Ohfuj S, Aoshima M, Suzuki K, Kondo K, Hirota Y. "Immunogenicity of influenza vaccine in patients with lung cancer under chemotherapy." Chest 2015;148(4_MeetingAbstracts):81A. doi:10.1378/chest.2270362

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