souseikai global clinical research center

Achievements - 2014

The list includes Japanese literature.


  • Ohfuji S, Fukushima W, Watanabe K, Sasaki S, Yamagami H, Nagahori M, Watanabe M, Hirota Y, for the Japanese Case-Control Study Group for Ulcerative Colitis. "Pre-Illness Isoflavone Consumption and Disease Risk of Ulcerative Colitis: A Multicenter Case-Control Study in Japan." PLoS One. 2014 Oct 14;9(10): e110270. doi: 10.1371/journal.pone.0110270. eCollection 2014
  • Mugitani A, Ito K, Irie S, Eto T, Ishibashi M, Ohfuji S, Fukushima W, Maeda A, Hirota Y. for the Fukuoka Pediatricians Group for Vaccine Efficacy. "Immunogenicity of the trivalent inactivated influenza vaccine in young children less than 4 years of age, with a focus on age and baseline antibodies." Clinical and Vaccine Immunology 21(9): 1253-1260, 2014.
  • Fukata N, Okazaki K, Omiya M, Matsushita M, Watanabe M, The Members of the Ministry of Health and Welfare of Japan’s Inflammatory Bowel Diseases Study Group (the 7th author of the 70 research members). "Hematologic malignancies in the Japanese patients with inflammatory bowel disease." Gastroenterol 49:1299-1306, 2014.
  • Yotani N, Ishiguro A, Sakai H, Ohfuji S, Fukushimna W, Hirota Y. "Factor-associated caregiver burden in medically complex patients with special health care needs." PediatInt 56(5):742–747,2014.
  • Kiyohara C, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y, and Kyushu Sapporo SLE (KYSS) Study Group. "Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages." Arthritis Care Res 66(7): 1048-1056, 2014. (32nd author of the study group in alphabetical order)
  • Ohfuji S, Fukushima W, Sasaki Y, Tamori A, Kurai O, Kioka K, Maeda K, Maeda A, Hirota Y. "Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients." Liver Int 34(5): 700-706, 2014.
  • 大藤さとこ、廣田良夫: 「【日常診療とワクチン】糖尿病患者とワクチン」『成人病と生活習慣病』44(12): 1436-1439. 2014.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Murakami K, Hirota Y; Osaka Maternal and Child Health Study Group. "Dietary patterns in infancy and their associations with maternal socio-economic and lifestyle factors among 758 Japanese mother-child pairs: the Osaka Maternal and Child Health Study." Matern Child Nutr. 10(2):213-225, 2014.

Achievements - 2013

The list includes Japanese literature.


  • Fukushima W, Yamamoto T, Takahashi S, Sakaguchi M, Kubo T, Iwamoto Y, Hirota Y; for the Idiopathic ONFH Multicenter Case-Control Study Group. "The effect of alcohol intake and the use of oral corticosteroids on the risk of idiopathic osteonecrosis of the femoral head." Bone Joint J 95-B(3): 320-325, 2013.
  • Ohfuji S, Fukushima W, Tamori A, Maeda K, Maeda A, Hirota Y. "Immunogenicity of influenza A(H1N1)pdm09vaccine and the associated factors on lowered immune response in patients with hepatitis C." Influenza Other Respi Viruses. 7: 456-465, 2013.
  • Tanaka K, Miyake Y, Sasaki S, Hirota Y. "Infant feeding practices and risk of dental caries in Japan: The Osaka Maternal and Child Health Study." Pediatric Dentistry 35(3):267-271, 2013.
  • 江藤隆、松原恵、永水美里、石橋元規、都留智巳、伊藤一弥、大藤さとこ、福島若葉、入江伸、廣田良夫 「糖尿病患者におけるインフルエンザA(H1N1)pdm09ワクチンの免疫原性」『糖尿病』56(4): 219-226, 2013.
  • Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, and Fukuoka Kinki Parkinson’s disease study group. "MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson’s disease: a case-control study in Japan." Drug MetabPharmacokinet. 28(2):138-143. 2013.
  • Palacpac NMQ, Ntege E, Yeka A, Balikagala B, Suzukib N, Shirai H, Yagi M, Ito K, Fukushima W, Hirota Y,Nsereko C, Okada T, Kanoi BN, Tetsutani K, Arisue N, Itagaki S, Tougan T, Ishii KJ, Ueda S, Egwang T, Horii T. "Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36." PLoS ONE 8(5): e64073. doi:10.1371/journal.pone.0064073 (May 28, 2013)
  • Kondo K, Ohfuji S, Fukushima W, Takahashi S, Miura H, Takasugi S, Iwamoto Y, Hirota Y. "Association between dietary habits and knee osteoarthritis in Japanese older adults: A cross-sectional study." Orthop Muscul Syst 2013;2:1, 2:120. doi:10.4172/2161-0533.1000120. (http://dx.doi.org/10.4172/2161-0533.1000120)
  • 廣田良夫:「インフルエンザワクチンの有効性」『臨床と微生物』40(4):353-357, 2013.
  • 福島若葉、大藤さとこ、廣田良夫:「臨床医のための疫学と統計学の基本」『日整会誌』 87: 563-571, 2013.
  • Tanaka K, Miyake Y, Sasaki S, Hirota Y. "Socioeconomic status and risk of dental caries in Japanese preschool children: the Osaka Maternal and Child Health Study." J Public Health Dentistr 73:217–223, 2013.
  • 原めぐみ、大藤さとこ、福島若葉、廣田良夫「ワクチン疫学研究の原理と方法:新型インフルエンザワクチンの免疫原性と有効性の評価」『日本衛生学雑誌』68(3) : 153-160,2013.
  • Ohfuji S, Fukushima W, Sasaki Y, Tamori A, Kurai S, Kioka K, Maeda K, Maeda A, Hirota Y. "Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients." Liver International. 2013. DOI: 10.1111/liv.12295
  • Sasaki Y, Ohfuji S, Fukushima W, Tamori A, Enomoto M, Habu D, Iwai S, Uchida-Kobayashi S, Fujii H, Shiomi S, Kawada N, Hirota Y. "Effect of caffeine-containing beverage consumption on serum alanine aminotransferase level in patients with chronic hepatitis C virus infection: A hospital-based cohort study." PLOS ONE, December 2013, Volume 8, Issue 12, e83382.
  • 大藤さとこ、廣田良夫「インフルエンザワクチンの有効性」『小児内科』45(11) : 2005-2008. 2013.
  • 廣田良夫.「インフルエンザワクチン無効論は克服できたか:疫学の視点から」『日小医会報』46 :16-18, 2013.
  • Momoki C, Hayashi F, Tanaka R, Miyata S, Hayashi Y, Otuka A, Nakahira M, Yamagishi K, Hirata S, Ohfuji S, Fukushima W, Hirota Y. "Calf circumference and body mass index are more useful predictors of hospitalization than the minik nutritional assessment in institutionalized Japanese elderly." Journal of Aging research & Clinical Practice 2(1): 51-56, 2013.

Achievements - 2012

The list includes Japanese literature.


  • 大藤さとこ、乾未来、井手悠一郎、福島若葉、廣田良夫:「炎症性腸疾患-病因解明と診断・治療の最新知見-、Ⅱ.炎症性腸疾患の疫学、炎症性腸疾患の危険因子」『日本臨床』 70(S1) : 52-55, 2012.
  • Kobayashi M, Ohfuji S, Fukushima W, Maeda A, Maeda K, Fujioka M, Hirota Y. "Immunogenicity and reactogenicity of a monovalent inactivated 2009 influenza A vaccine in adolescents: with special reference to pre-existing antibody." J Pediatr160(4) :632-637, 2012.
  • 大藤さとこ、神宮司誠也、近藤亨子、高橋真治、廣田良夫:「変形性股関節症の病院と疫学」『臨床整形外科』47(4):301-306, 2012.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Murakami K, Hirota Y and Osaka Maternal and Child Health Study Group. "Maternal dietary patterns in pregnancy and fetal growth in Japan: the Osaka Maternal and Child Health Study." Br J Nutr 107(10): 1526–1533, 2012.
  • Okubo H, Miyake Y, Sasaki S, Murakami K, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M and the Fukuoka Kinki Parkinson's Disease Study Group. "Dietary pattern and risk of Parkinson's disease: a case-control study in Japan." Europ J Neurol. 19:681-688, 2012.
  • 廣田良夫「ワクチン有効性評価に係る疫学の基礎知識」『日本小児臨床薬理学会雑誌』24(1) : 28-32, 2012.
  • Tanaka K, Miyake Y, Sasaki S, Hirota Y. "Dairy products and calcium intake during pregnancy and dental caries in children." Nutrition Journal 11:33, 2011.doi:10.1186/1475-2891-11-33
  • Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, and Fukuoka Kinki Parkinson’s Disease Study Group. "SNCA polymorphisms, smoking, and sporadic Parkinson’s disease in Japanese." Parkinsonism Relat Disord 18(5) : 557-561, 2012.
  • Miyake Y, Tanaka K, Sasaki S, Hirota Y. "Parental employment, income, education and allergic disorders in children: a prebirth cohort study in Japan." Int JTubercLung Dis 16(6): 756-761, 2012.
  • 大藤さとこ、渡辺憲治、廣田良夫「炎症性腸疾患はなぜ増えているのか-疫学と環境因子-」『Medical Practice』 29(7) :1119-1120, 2012.
  • 前田章子、森川佐依子、加瀬哲男、入江伸、廣田良夫「インフルエンザウイルス抗体価測定に関する問題点-2006/07シーズンワクチン株A/広島/52/2005(H3N2)の感受性に関する検討-」『感染症学雑誌』86(4) : 400-404, 2012.
  • 勝田早希、福島若葉、近藤亨子、松永一朗、撫井賀代、廣田良夫「都市部の基本健康診査受診者における喫煙と生活習慣病の関連」『日本公衛誌』59(7) : 447-456, 2012.
  • Kobayashi M, Ohfuji S, Fukushimna W, Sugiura S, Kohdera U, Ito Y, Ide S, Ohbu K, Hirota Y. "Pediatric Hospitalizations with Influenza A infection during the 2009-2010 pandemic in five hospitals in Japan." Pediatr Int.54(5): 613–618, 2012.
  • 廣田良夫「インフルエンザ:ワクチン評価と疫学研究手法」『日本小児科学会雑誌』116(10):1496-1502, 2012.
  • Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama Hi, Hirota Y, Nagai M, and Fukuoka Kinki Parkinson’s Disease Study Group. "Lack of association between BST1 polymorphisms and sporadic Parkinson’s disease in a Japanese population." Journal of the Neurological Sciences 323 : 162–166, 2012.
  • Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M and the Fukuoka Kinki Parkinson’s Disease Study Grou. "UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan." BMC Neurology 2012,12:62.(28 Jul 2012)http://www.biomedcentral.com/1471-2377/12/62
  • Ohno Y, Ishimura E, Naganuma T, Kondo K, Fukushimae W, Mui K, Inaba M, Hirota Y. "Prevalence of and factors associated with chronic kidney disease (CKD) in Japanese subjects without notable chronic diseases, undergoing an annual health checkup." Kidney Blood Press Res 36:139-148, 2012.
  • Fukushima W, Ohfuji S, Deguchi M , Kawabata K, Hatayama H, Yoshida H, Maeda A, Hirota Y. "Effectiveness of an influenza A (H1N1) 2009 monovalent vaccine among Japanese pregnant women: A prospective observational study assessing antibody efficacy." Vaccine 30: 7630- 7636, 2012.
  • Murai Y, Ohfuji S, Fukushima W, Tamakoshi A, Yamaguchi S, Hashizume M, Moriyasu F, Hirota Y. "Prognostic factors in patients with idiopathic portal hypertension: Two Japanese nationwide epidemiological surveys in 1999 and 2005." Hepatology Research 42(12):1211–1220, 2012.
  • Takahashi S, Fukushima W, Kubo T, Iwamoto Y, Hirota Y, Nakamura H. "Pronounced risk of nontraumatic osteonecrosis of the femoral head among cigarette smokers who have never used oral corticosteroids: a multicenter case-control study in Japan." J Orthop Sci. 17(6):730-736, 2012.

Achievements - 2011

The list includes Japanese literature.


  • Miyake Y, Fukushima W, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, and Fukuoka Kinki Parkinson’s Disease Study Group. "Dietary intake of antioxidant vitamins and risk of Parkinson’s disease: a case-control study in Japan." Eur J Neurol 18:106-113, 2011.
  • Miyake Y, Sasaki S, Tanaka K, Hirota Y. "Maternal B vitamin intake during pregnancy and wheeze and eczema in Japanese infantsaged 16-24 months: The Osaka Maternal and Child Health Study." Pediatr Allergy Immunol 22:69-74, 2011.
  • Miyake Y, Tanaka K, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, and Nagai M, and the Fukuoka Kinki Parkinson’s Disease Study Group. "Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson’s Disease: a case-control study in Japan." Parkinsonism Related Disorders 17(2):112-116, 2011.
  • Jingushi S, Ohfuji S, Sofue M, Hirota Y, Itoman M, Matsumoto T, Hamada Y, Shindo H, Takatori Y, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Fujii G, Ohashi H, Iwamoto Y, Miyanishi K, Iga T, Takahira N, Sugimori T, Sugiyama H, Okano K, Karita T, Ando K, Hamaki T, Hirayama T, Iwata K, Nakasone S, Matsuura M, and Mawatari T. "Osteoarthritis hip joints in Japan: involvement of acetabular dysplasia." J OrthopSci 16(2):156-164, 2011.
  • Miyake Y, Tanaka K, Sasaki S, Hirota Y. "Employment, income, and education and risk of postpartum depression: The Osaka Maternal and Child Health Study." J Affect Disorders. 130(1): 133-137, 2011.
  • Ohfuji S, Fukushima W, Deguchi M, Kawabata K, Yoshida H, Hatayama H, Maeda A, Hirota Y. "Immunogenicity of a monovalent 2009 influenza A(H1N1) vaccine among pregnant women: lowered antibody response by prior seasonal vaccination." J Infect Dis 203(9):1301-1308, 2011.
  • Miyake Y, Tanaka K, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M and the Fukuoka Kinki Parkinson’s Disease Study Group. "Dietary intake of metals and risk of Parkinson’s disease: a case-control study in Japan." J NeurolSci 306(1):98-102, 2011.
  • Tanaka K, Miyake Y, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M and the Fukuoka Kinki Parkinson’s Disease Study Group. "Intake of Japanese and Chinese teas reduces risk of Parkinson’s disease." Parkinsonism RelatDisord 17(6):446-450, 2011.
  • Tanaka K, Miyake Y, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M and the Fukuoka Kinki Parkinson’s Disease Study Group. "Occupational risk factors for Parkinson’s disease: a case-control study in Japan." BMC neurology 11:83, 2011.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Murakami K, Hirota Y, and the Osaka Maternal and Child Health Study Group. "Dietary patterns during pregnancy and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study." Br J Nutr 105(8):1251-1257, 2011.
  • 大藤さとこ、福島若葉、廣田良夫「潰瘍性大腸炎-長期経過観察例の諸問題.再燃の因子となるものは?」『臨床消化器内科』26(8):1115-1124, 2011.
  • 福島若葉、廣田良夫「特発性大腿骨頭壊死症の全国疫学調査か」『MB Orthop』 24(8): 7-11, 2011.
  • 日本整外科学会マニュアル作成委員会(岩本幸英、久保俊一、松本忠美、渥美敬、菅野伸彦、田中栄、山本卓明、廣田良夫、長澤浩平).「特発性大腿骨頭壊死症」『重篤副作用疾患別対応マニュアル 第5集』P175-193(財)日本医薬情報センター.東京、2011.
  • Kiyohara C, Miyake Y, Koyanagi Midori, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N,Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki Parkinson's Disease Study Group. "Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson’s disease in a Japanese population." BMC Neurol 11(1):89 (2011) PMID 21781348.
  • Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H,HirotaY, NagaiM for the Fukuoka Kinki Parkinson’s Disease Study Group. APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population. J Neural Transm 118(9):1335-1344, 2011.
  • 福島若葉、廣田良夫.「大腿骨頭壊死症-関節温存手術とその限界.特発性大腿骨頭壊死症の全国疫学調査から」『Orthopaedics』 24(8):7-11, 2011.
  • Tsujio T, Nakamura H, Terai H, Hoshino M, Namikawa T, Matsumura A, Kato M, Suzuki A, Takayama K, Fukushima W, Kondo K, Hirota Y, Takaoka K. "Characteristic radiographic or magnetic resonance images of fresh osteoporotic vertebral fractures predicting potential risk for nonunion: A prospective multicenter study." Spine 36(15): 1229-1235, 2011.
  • Miyake Y, Okubo H, Sasaki S, Tanaka K, Hirota Y. "Maternal dietary patterns during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study." Pediatr Allergy Immunol 22(7): 734–741, 2011.
  • 大藤さとこ、廣田良夫「インフルエンザ」『綜合臨牀』 60(11): 2275-2281, 2011.
  • Miyake Y, Tanaka K, Yasutake A, Sasaki S, Hirota Y. "Lack of association of mercury with risk of wheeze and eczema in Japanese children: The Osaka Maternal and Child Health Study." Environ Res 111(8):1180-1184, 2011.
  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Murakami K, Hirota Y, and Osaka Maternal and Child Health Study Group. "Nutritional adequacy of three dietary patterns defined by cluster analysis in 997 pregnant Japanese women: the Osaka Maternal and Child Health Study." Pub Hlth Nutr, 14(4): 611–621, 2011.
  • Hara M, Hanaoka T, Mizushima T, Honma J, Maeda K, Ohfuji S, Tanaka K, Hirota Y. "Diminished immunogenicity to pandemic H1N1 2009 influenza vaccine in subjects with severe motor and intellectual disability." Vaccine 29(46): 8323-8329, 2011.
  • Miyake Y, Kiyohara C, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Sasaki S, Hirota Y. "Case-control study of eczema associated with IL13 genetic polymorphisms in Japanese children." Int Arch Allergy Immunol. 154:328-335, 2011.

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